ISDIN Eryfotone AK-NMSC - adjuvant in actinic keratosis and non-melanoma skin cancer is now available in Romania. Summer brings with it sunshine and joy, but it also brings the need for more skin care and protection from sunburn. You already know, right? Sun protection is a must no matter where you are, because radiation reaches us even when it's cloudy outside. Unprotected sun exposure is responsible for both photo-aging and most skin tumors. So, a sunburn is not a trivial thing that passes, as it affects cellular DNA, which could lead to skin cancer.

Sun damage, the best known of which are photoaging and photocarcinogenesis, is caused by exposure to UV radiation and can become chronic over time. UVB rays cause direct damage as they are absorbed by DNA and cause mutations, while UVA rays act indirectly, causing photosensitivity and oxidative stress. But both types of radiation can lead to skin cancer over time by damaging the skin's natural defenses.

That's why sunscreen is essential if we want to stay healthy! But have you heard the good news? ISDIN has also launched in Romania the product Eryfotona AK-NMSC - an adjuvant in actinic keratosis and non-melanoma skin cancer.

ISDIN Eryfotona AK-NMSC provides prevention and protective adjuvant treatment in actinic lesions (at higher risk of developing skin cancer) and non-melanoma skin cancer. The innovative product incorporates patented DNA Repairsomes® technology: SPF 100+ UVB, UVA, VISIBLE LIGHT, IR-A and liposome-encapsulated photolysis (molecules that carry photoreactivating enzymes that are responsible for repairing UV-induced DNA mutations). The use of Eryfotona AK-NMSC fluid reduces and ameliorates the subclinical cancerization field associated with actinic keratosis and other forms of non-melanoma skin cancer, with numerous clinically proven results since its launch on the Spanish market in 2008

Rsolar radiation causes photocarcinogenesis

The DNA damage caused by UVB rays leads to changes in the cell membrane and intracellular free radicals cause changes in cell homeostasis, ultimately leading to the formation of sunburn cells. These are actually keratinocytes undergoing apoptosis as a protective mechanism against the carcinogenic effects of UVB. Mitochondria act as the main checkpoint, and dysregulation of the signaling cascade systems can lead to the development of skin cancer. While p53, the main tumor suppressor, is present in normal cells, it is inactivated in cells with the burn by mutations resulting from damage to the AND.

Photo protection is necessary

Photoprotection is the key to preventing photoaging, pigmentation spots and skin cancer. If, however, chronic sun damage has accumulated in the form of actinic keratoses or non-melanoma skin cancer, products that combine high sun protection with active ingredients that help repair DNA are available.

What is photololysis?

Photolyase is a DNA repair enzyme that humans don't have, but is found naturally in plants and blue-green algae. It's photoactivated by visible light, and studies have shown that applying it to the skin decreases 40-45% DNA damage caused by UV rays, suggesting that this damage can be repaired.

Eryfotone AK-NMSC ISDIN contains photolyase encapsulated in liposomes, those molecules that ensure skin penetration and activate the repair of DNA damaged by sun exposure. This enzyme essentially binds to the UV damage and reactivates DNA repair. Studies show that not only photoprotection is key, but that photorepair is necessary to prevent chronic sun damage. Clinical evidence demonstrates that DNA repair enzymes improve the removal of DNA damage- and reduce the occurrence of new actinic keratosis lesions and therefore their effectiveness in preventing skin cancer.

The use of DNA repair enzymes together with e photoprotection is the best choice for all people with a high level of sun exposure and for those at higher risk of developing skin cancer. Studies show that this dual action enhances the removal of DNA damage, reduces the occurrence of new actinic keratosis lesions and increases the regression of existing lesions...

Good guard passes danger

• Avoid sun exposure between 12am and 4pm.
• Wear dense, natural fabrics, a hat and sunglasses
• Apply broad spectrum (UVA and UVB) SPF 30-50 sunscreens and lotions.

Did you know that?

• 80% of UV rays pass through clouds and haze, and 50% of UVA exposure comes from reflected light, even when you're sitting in the shade or in the water.
• There is no 100% sunscreen. Even SPF50+ suncare products (which include formulas with an SPF greater than 60) let some rays penetrate and allow skin to tan.
• The optimum amount of cream for effective protection is 2 mg/cm² of skin, about the size of a golf ball for the whole body.
• If you choose a spray product (spray or oil), 10 to 15 sprays per area are needed to properly protect the skin and ensure that the product is evenly distributed on the skin.
• 1 in 3 diagnosed cancers is skin cancer? 90% develops into keratinocytes, carcinoma, and the remaining 10% are malignant tumors, melanoma. ISDIN products can be found in physical and online pharmacies

https://www.isdin.com/en/product/eryfotona/ak-nmsc-spf-100-fluid-eng

https://comenzi.farmaciatei.ro/ingrijire-personala/protectie-solara/produse-cu-spf-pentru-fata/fluid-cu-spf-100-eryfotona-ak-nmsc-50-ml-isdin-p360721

Good to know:

What is your skin phototype?

Some people burn as soon as they sit in the sun, while others can relax for hours without any discomfort. The difference is the amount of melanin naturally present in the skin. The lower the phototype, the greater the need for sun protection! Experts have identified 6 phototypes:

PHOTO TYPE 1: fair skin/red or blond hair (often freckled) - Always burns, never tans

PHOTO TYPE 2: fair skin/blond, red to light brown hair (sometimes with freckles) - Frequent sunburn, very little or very slow tanning

PHOTO TYPE 3: medium skin/fair to dark brown complexion - occasional sunburn, gradual tan

PHOTOTIP 4: light brown/brown to black skin - occasional sunburn, tan quickly

PHOTOTIP 5: dark brown skin/black hair - rare sunburn, intense tan

PHOTOTIP 6: Black leather/black hair - It almost never burns.